Pluto Bioinformatics

GSE69054: An Nfic-Hedgehog Signaling Cascade Regulates Tooth Root Development

Bulk RNA sequencing

This study aimed to perform transcriptome profiling of Nfic-/- and corresponding control tooth germ at root initiation stage to identify differentially expressed for key regulators of root development.; Coordination between the Hertwigs Epithelial Root Sheath (HERS) and apical papilla (AP) is crucial for proper root development process. The Hedgehog (Hh) signaling pathway and Nfic are both involved in tooth root development. SOURCE: Vasu Punj (vasu.punj@med.usc.edu) - University of Southern California