Obesity is associated with an increased incidence of high grade prostate cancer (PC) and worse prognosis for PC patients. Recently, we showed in men that obesity-related periprostatic white adipose tissue (WAT) inflammation, characterized by macrophages surrounding dead or dying adipocytes forming crown-like structures, was associated with high grade PC.  Possibly, interventions that suppress periprostatic WAT inflammation will improve outcomes for men with PC.  Here, we tested the hypothesis that supplemental 17-estradiol (E2) could decrease periprostatic WAT inflammation in obese male mice. SOURCE: Akanksha Verma (akv3001@med.cornell.edu) -  Weill Cornell Medical College

Pluto Bioinformatics

GSE123357: Mouse Estrogen Treatment Study Analysis of Peri-prostatic Fat