Pluto Bioinformatics

GSE69007: Dnmt3l-knockout donor cells improve somatic cell nuclear transfer reprogramming efficiency

Bulk RNA sequencing

We found that Dnmt3l-KO donor cells display decreased levels of H3K9me3 and H3K27me3 accumulation, higher level of active histone mark H3K27ac and increased cytoplasmic localization of HDAC1, implicating a permissive epigenetic state beneficial for nuclear reprogramming. SOURCE: Shau-Ping Lin (shaupinglin@ntu.edu.tw) - National Taiwan University