Intestinal stem cells (ISCs) residing in the crypts are critical for the continual self-renewal and rapid recovery of intestinal epithelium. The regulatory mechanism of ISCs is not fully understood. Here we report that CREPT, a recently identified tumor-promoting gene, is preferably expressed in the crypts, where the ISCs reside, but not in the villi. To explore the function of CREPT in ISCs, we isolated crypts to perform Next generation sequencing. SOURCE: Liu Yang (yalaceline@hotmail.com) -  Tsinghua University

Pluto Bioinformatics

GSE143695: Gene expression profiles of WT and Vil-CREPTKO intestinal cyrpts