Pluto Bioinformatics

GSE86460: Comparison of mRNA expression profiles of 3q21q26 and 3q21q26::Gata2+/ mouse leukemic cells

Bulk RNA sequencing

The 3q21q26 mice harboring a transgene recapitulating GATA2 enhancer-drived EVI1 overexpression in inv(3)(q21q26) allele develop leukemia. Gata2 heterogenous deletion accelerates leukemogenesis of the 3q21q26 mice. To get insights into the couse of the acceleration of leukemogenesis, RNA-sequencing analysis was performed using B220+Gr1cKit+ populations containing leukemia-initiating cells in bone marrows of leukemic 3q21q26 and 3q21q26::Gata2+/ mice. SOURCE: Masayuki Yamamoto (suzukimikiko@med.tohoku.ac.jp) - Tohoku University Graduate School of Medicine