Pluto Bioinformatics

GSE110248: Gene expression profiling of cutaneous T cell lymphoma cell lines and primary tumor samples treated with mechlorethamine and romidepsin.

Bulk RNA sequencing

In this study, we demonstrated the synergistic effect of the mechlorethamine-romidepsin combination in cutaneous T cell lymphoma cell lines and CD4+ T cells derived from patients with Sezary Syndrome. We identify the signaling pathways specifically perturbed under treatment with mechlorethamine-romidepsin combination. SOURCE: Stuart,Aidan,Quinn (saq2106@columbia.edu) - Adolfo Ferrando Columbia University