Purpose: Mouse BMDM is the universal cell type of studying innate immunity.This study was to analyze LPS induced innate immune respone and the relationship between serine synthesis pathway and  LPS induced innate immune respone;	Methods: BMDM cells were treated with or without LPS for 6 hours in the pressence of phgdh inhibitor or not. Then mRNA profiles of these samles were generated by High-throughput sequencing analysis, in triplicate, using illumina HiSeqTM 2000. And the differencial mRNA profiles were analyzed.;	Results: mRNA profiles about 23002 genes were analyzed, and differencial expression profiles were compared .;	Conclusions: Our study represents the first detailed analysis of transcriptomes of mouse BMDM treated with LPS and phgdh inhibitor, with biologic replicates, generated by RNA-seq technology. This data was useful to analyze the relationship between serine synthesis pathway and  LPS induced innate immune respone SOURCE: Di Wang (diwang@zju.edu.cn) -  ZheJiang university

Pluto Bioinformatics

GSE126084: High-throughput sequencing Analysis of mouse BMDM cell Transcriptomes