Innate lymphoid cell (ILC) subsets that mirror helper T cells in their effector cytokine profiles have recently emerged as central players in both homeostatic and inflammatory conditions.  Like their Th1, Th2 and Th17/Th22 helper T cell counterparts, ILC subsets are categorized based on their expression of specific transcription factors and effector cytokines:  group 1 ILC (ILC1) express T-bet and IFN-; group 2 ILC (ILC2) express GATA-3 and type 2 effector cytokines such as IL-13 and IL-5; and group 3 ILC (ILC3) express RORgt and the cytokines IL-22 and/or IL-17.  Under this nomenclature, natural killer (NK) cells and lymphoid tissue inducers (LTi) are considered ILC1 and ILC3, respectively.  ILC1 contain both CD4+ and CD4- populations, but whether this phenotypic characteristic reflects functional differences between these two populations is unknown.  These studies examine the gene expression profiles of CD4+ vs CD4- ILC1 in a cohort of healthy control subjects. SOURCE: Scott Presnell (SPresnell@benaroyaresearch.org) -  Benaroya Research Institute

Pluto Bioinformatics

GSE69596: Gene expression analysis of CD4+ and CD4- ILC1 subsets by RNAseq