Pluto Bioinformatics

GSE107932: Global transcriptional changes in U87MG glioblastoma cells upon shRNA-mediated TRIM52 knockdown

Bulk RNA sequencing

shRNA-mediated ablation of the RING-finger protein TRIM52 from multiple glioblastoma cell lines reduces proliferation and tumorigenesis. To identify gene signatures underlying this phenomenon, transcritional profile of TRIM52 knockdown cells was compared to control cells. Upon TRIM52 ablation, we find 278 differentially regulated genes. Gene ontology analysis reveals that many of the upregulated genes are associated with glycolysis and biosynthetic processes. SOURCE: Stefan Benke (stefan.benke@univie.ac.at) - Max F. Perutz Laboratories, University of Vienna