We sought to determine whether Ldh activity in SCC tumors is a marker of the cell type from which these cells arise, or a key metabolic activity important for tumor initiation or progression.  Here we show that genetic abrogation of Ldh enzyme activity in HFSC-mediated tumorigenesis had no effect on tumor number, time to tumor formation, tumor proliferation, epithelial to mesenchymal transition in tumors, gene expression in tumors, tumor pathology, or the immune response to tumors. SOURCE: James Joly (joly@usc.edu) - Nicholas Graham Lab University of Southern California

Pluto Bioinformatics

GSE111997: Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin