Pluto Bioinformatics

GSE149634: Single cell mapping of breast tumor stroma reveals dynamically evolving compositions of cancer-associated fibroblasts along tumor progression (bulk RNA-seq dataset)

Bulk RNA sequencing

Tumors are complex ecosystems, in which malignant and non-malignant cells engage in continuous interactions. Cancer associated fibroblasts (CAFs) are the most abundant non-malignant cells in the majority of carcinomas. The wide range of activities that CAFs perform suggests a dynamic and heterogeneous composition, yet tumor infiltrating CAF subpopulations remain poorly characterized. Here we used single cell RNA sequencing and index sorting to map CAFs at various stages of tumor progression and metastasis. SOURCE: Ido Amit (ido.amit@weizmann.ac.il) - Weizmann Institute of Science