Astrocyte responses to neuronal injury may be beneficial or detrimental to neuronal recovery, but the mechanism that determines these different responses are poorly understood. Transcriptional analysis showed that EphB1 induces a protective inflammatory signature in astrocytes, which is distinct from the response evoked by interleukin (IL)-6, which is known to have both pro- and anti-inflammatory properties. We demonstrate that this beneficial EphB1 induced signaling pathway is disrupted in astrocytes derived from human induced pluripotent stem cells (iPSC) of amyotrophic lateral sclerosis (ALS) patients. SOURCE: Christopher Sibley (c.sibley@imperial.ac.uk) -  Imperial College London

Pluto Bioinformatics

GSE102903: Neuronal EphB1 induces STAT3 activation in astrocytes, which is impaired in ALS models [Mm]