The granulosa cells in the mammalian ovarian follicle respond to gonadotropin signalling and are involved in the processes of folliculogenesis and oocyte maturation. Studies on gene expression and regulation in human granulosa cells are of interest due to their potential for estimating the oocyte viability and IVF success. The current study determined the mRNA profile by deep sequencing of the two intrafollicular somatic cell types: mural and cumulus granulosa cells isolated from women undergoing controlled ovarian stimulation and in vitro fertilization. SOURCE: Agne Velthut-Meikas Competence Centre on Reproductive Medicine and Biology

Pluto Bioinformatics

GSE46490: High-throughput RNA sequencing of human preovulatory cumulus and mural granulosa cells (mRNA)