Pluto Bioinformatics

GSE84961: Transcriptome analysis of lymphoid progenitors in Zbtb1-deficient mice

Bulk RNA sequencing

Purpose: Deficiency of Zbtb1 leads to the generation of myeloid cells from lymphoid progenitors when cultured in conditions that do not support myeloid development. We therefore analyzed how was the transcriptional signature altered by Zbtb1 deficiency in lymphoid progenitors ex vivo and after induction of a T-cell developmental program by co-culture with OP9-DL1 stroma cells. SOURCE: Damian Kovalovsky (damian.kovalovsky@nih.gov) - National Cancer Institute