Pluto Bioinformatics

GSE121224: An enhancer in the middle of the Ig locus orchestrates nuclear architecture to generate a diverse antigen receptor repertoire

Bulk RNA sequencing

Purpose:The goal of this study is to assess transcriptome profile in the absence of a potent enhancer located in the V gene region of the Ig locus in cell lines and mice; Methods: RNAseq from CD19+ cells from B6.RAG1-/- and E88-/-.RAG1-/- mice. RNAseq from 445.3, wild-type (WT) and E88-/-, pro-B cell lines SOURCE: Padmaja Natarajan (nataraja@scripps.edu) - Center for Computational Biology and Bioinformatics The Scripps Research Institute

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