Pluto Bioinformatics

GSE69168: Allelome.PRO A pipeline to define allele-specific genome features

Bulk RNA sequencing

We used RNA-seq data from mouse embryonic fibroblasts from F1 reciprocal crosses to determine a biologically relevant allelic ratio cutoff, and define for the first time an entire allelome. Furthermore, we show that Allelome.PRO detects differential enrichment of H3K4me3 over promoters from ChIP-seq data validating the RNA-seq results. SOURCE: Daniel AndergassenBarlow CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences