Pluto Bioinformatics

GSE135983: Integrin 31-dependent mRNA expression profile of hair bulge keratinocytes and their progeny during DMBA/TPA-mediated skin tumorigenesis

Bulk RNA sequencing

Integrin 31 in hair bulge population affects the tumor formation following DMBA/TPA carcinogenesis protocol, however linage tracing showed that hair bulge cells do not largely contributre to tumor mass. To investigate whether 31 might affect tumor promoting environment and to better understand its role in hair bulge population during skin tumorigenesis, we determined the expresison profile of hair bulge-originating keratinocytes isolted from 31KO and WT mice during initiation of tumorigenesis. SOURCE: Veronika Ramovs (v.ramovs@nki.nl) - A. Sonnenberg Netherlands Cancer Institute