Pluto Bioinformatics

GSE111904: Osmostress induced changes of chromatin architecture and transcription in mammalian cells [RNA-Seq, HiC]

Bulk RNA sequencing

Osmostress causes chromatin compaction and simultaneously triggers a massive transcriptional response in eukaryotic cells that is required for adaptation and cell survival. However, thus far it was unknown how changes of chromatin organization and ongoing DNA transcription are linked under hyper-osmotic conditions. In this study, we focused on elucidating the extend of chromatin reoganization upon hyper-osmotic shock, its reversibility and its link with active transcription in human T47D cells. SOURCE: Francesc Posas Cell Signaling Group, Universitat Pompeu Fabra