Pluto Bioinformatics

GSE91390: Distinct Brca1 mutations differentially reduce hematopoietic stem cell function

Bulk RNA sequencing

Mgbemena et al report that hematopoietic stem cells have an absolute requirement for Brca1 to survive. They also show that humanization of the mouse Brca1 e with a knocked-in BRCA1 cDNA, but not a mutant BRCA1/5382insC cDNA, fully substitutes for the mouse Brca1 during both embryonic development and hematopoiesis. SOURCE: Theo Ross (theo.ross@utsouthwestern.edu) - ND3.202 UT Southwestern Medical Center