Pluto Bioinformatics

GSE145317: Identification of endothelial derived factors that promote metastasis III

Bulk RNA sequencing

To identify endothelial-derived factors that may instructively drive cancer metastasis, we generated a new mouse model that allows endothelial-specific ribosomal tagging. We crossed the RiboTag (Rpl22fl/flHA) mice with the endothelial inducible Cre line Cdh5(PAC)-CreERT2 mice. Endothelial derived ribosome-associated mRNA-sequencing was performed from highly metastatic B16F10 and poorly metastatic B16F0 tumours. SOURCE: Bernardo Tavora (btavora@mail.rockefeller.edu) - Tavazoie The Rockefeller University