Pluto Bioinformatics

GSE114686: Total RNA profiles in response to four tyrosine kinase inhibitors in human induced pluripotent stem cell-derived cardiomyocytes

Bulk RNA sequencing

To define molecular markers of tyrosine kinase inhibitor-induced cardiotoxicity, we measured transcriptome changes in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) treated with one of four tyrosine kinase inhibitors (Erlotinib, Lapatinib, Sorafenib, or Sunitinib) displaying a range of mild to severe cardiotoxicity or a vehicle-only control (DMSO). Gene expression changes were assessed at the cell population level using total RNA-seq, which measured levels of both mRNAs and non-coding RNAs.hiPSC-CMs used in this study were the Cor.4U cells purchased from Ncardia. SOURCE: Robert,Patrick,Sheehan (sheehan.robertp@gmail.com) - Harvard Medical School