Recent studies suggest that the activation of the innate immune system is an integral part of Parkinsons disease (PD) pathology. Monocytes have a critical role as effectors and regulators of the innate immune system, and a recent expression quantitative trait locus (eQTL) study links monocytes to PD. Patients diagnosed with PD according to the National Institute of Neurological Disorders and Stroke  diagnostic criteria for PD were included. We applied a standardized procedure with blood drawing from fasting participants. PD patients with Hoehn and Yahr > 2 and/or cognitive impairment were not recruited. Participants with a history of cancer, infectious diseases within the past three months, or taking anti-inflammatory drugs were excluded. Altogether, we analyzed the monocytic transcriptome profiles of 10 PD patients and 9 age- and sex-matched controls using mRNA sequencing. SOURCE: Jenhan Tao (jenhantao@gmail.com) - Glass UC San Diego

Pluto Bioinformatics

GSE88888: Monocyte transcriptome differences in early stage Parkinsons disease patients