Pluto Bioinformatics

GSE111347: RNA-sequencing of Adult Mouse Pillar and Deiters Supporting Cells of the Organ of Corti

Bulk RNA sequencing

To understand the basic biological properties of supporting cells of the mammalian inner ear, we examined the transcriptome of adult pillar and Deiters cells. Morphologically distinct pillar and Deiters cells were isolated from the organ of Corti from adult CBA/J mice. One thousand pillar and Deiters cells were separately collected for each biological replicate, using the suction pipette technique. RNA sequencing of three biological replicates, each with two technical repeats, was performed. The resulting sequenced reads were mapped. Comparisons between pillar cells and Deiters cells allow identification of enriched genes, as well as differentially expressed genes that result in cellular specialization. Our dataset provides an extensive resource for understanding the molecular mechanisms underlying morphology, function, and pathology of adult mouse pillar and Deiters cells. SOURCE: David,ZZ,He (davidhe@creighton.edu) - Creighton University