NSD2 (also known as Whsc1, MMSET) play a role in H3K36 methyl transferase. Here we showed that 199 ISGs of the total 393 ISGs after 2h IFN treatment were up regulated in NSD2 KO MEFs, suggesting negatively regulate ISGs induction. IFN pretreatment creates transcriptional memory. In this study we identified 129 ISGs were memory ISGs and 40 ISGs were non-memory ISGs. SOURCE: Mahesh Bachu (mahesh.bachu@nih.gov) - SMGI NIH

Pluto Bioinformatics

GSE97278: Genome-wide mRNA expression profiling of WT MEFs and NSD2 KO MEFs