We investigated roles of KRAS on stemness maintenance and differentiation propensity in the context of induced pluripotent stem cells (iPSCs) using isogenic KRAS mutant (G13C/WT) and wild-type (WT/WT) iPSCs from the same RAS-associated autoimmune lymphoproliferative syndrome-like disease (RALD) patients. RNA-seq analysis was conducted to compare gene expression profiles of WT/WT and G13C/WT iPS cells after in vitro differentiation. We found some differences of gene expression profiles regarding stemness and linage markers in the two genotypes. SOURCE: Kenji Kubara (k-kubara@hhc.eisai.co.jp) -  Eisai Co., Ltd.

Pluto Bioinformatics

GSE111345: RNA-seq analysis of RALD iPSCs after in vitro differentiation