Pluto Bioinformatics

GSE121117: SHP2 Drives Adaptive Resistance to ERK Signaling Inhibition in Molecularly Defined Subsets of ERK-dependent Tumors

Bulk RNA sequencing

We performed RNA sequencing analysis using NextSeq500 to identify drivers that mediate feedback RAS activation in BRAF(V600E) cells that are SHP2 independent. SOURCE: Ravi Sachidanandam (ravi.mssm@gmail.com) - sachidanandam Icahn School of Medicine at Mount Sinai