Ets1-/- mice have an increase in B cell differentiation to plasma cells and increased serum immunoglobulin levels. The genes in B cells that are transcriptionally regulated by Ets1 and help regulate B cell differentiation are largely unknown. Here, we identify Ets1-regulated target genes in B cells using ChIP-seq and RNA-seq analysis. We found that Ets1 targets  genes associated with immune response, mature B cell differentiation and regulation of B cell activation. SOURCE: Prontip Saelee (prontips@buffalo.edu) -  University at Buffalo

Pluto Bioinformatics

GSE83796: Analysis of gene expression profiles in wild-type vs Ets1-/- follicular B cells