In an effort to identify biomarkers of recurrence, we have performed global RNA-sequencing on 106 formalin-fixed, paraffin-embedded (FFPE) prostatectomy samples from 100 patients at three independent sites, and identified a new set of biomarkers of biochemical recurrence composed of a 24-gene panel. We validated this 24-gene panel on an independent publicly available dataset of 140 patients and this new panel outperformed previously published markers based on cell proliferation gene sets in terms of prediction of biochemical recurrence (BCR).  In addition we identified differences in gene expression between Gleason Pattern 4+3 and Gleason Pattern 3+4 tumors. SOURCE: Carlos Moreno (cmoreno@emory.edu) - Whitehead Research Building, Room 105J Emory University

Pluto Bioinformatics

GSE54460: RNAseq Analysis of Formalin-Fixed Paraffin-Embedded Prostate Cancer Tissues