Pluto Bioinformatics

GSE58365: The BCL6 RD2 domain governs commitment of activated B-cells to form germinal centers

Bulk RNA sequencing

Our data demonstrated that Bcl6 directly binds and represses trafficking receptors S1pr1 and Grp183 by recruiting Hdac2 through the RD2 domain. Deregulation of these genes impairs B-cell migration and may contribute to the Germinal Center failure in Bcl6RD2MUT mice. SOURCE: Yanwen Jiang (yaj2001@med.cornell.edu) - Weill Cornell Medical College