The goal of this study is to investigate the role of deregulated c-MYC in cooperation with activated NeuNT (mutated rat HER2) in mammary tumor molecular heterogeneity.  We monitored female mice through two cycles of pregnancy/lactation in order to activate Blg-Cre expression in mammary gland after the second cycle.  MYC-NeuNT mice develop tumors between 4 and 12 weeks post Blg-Cre activation, H&E images from these tumors showed histologic heterogeneity.  NeuNT mice developed tumors between 28 to 44 weeks post Blg-Cre activation that also showed histologic heterogeneity. SOURCE: Tyler Risom (tyler.risom@gmail.com) - Dr. Rosalie Sears Oregon Health & Science University

Pluto Bioinformatics

GSE132528: Expression of deregulated MYC with activated NeuNT in mammary gland developed mammary tumors with molecular heterogeneity