Pluto Bioinformatics

GSE112823: The gene expression profiles of antigen-primed wildtype and Ddit3-/- CD8 Pmel T cells

Bulk RNA sequencing

T cell undergoes ER stress during regular priming which may lead to T cell dysfunction in cancer. ER stress downstream sensor Chop (encoded by Ddit3 gene) negatively regulates CD8 T cell function and cytotoxicity. Because Chop is a C/EBP homologous transcription factor, we sorted antigen-primed wildtype or ddit3-/- Pmel CD8 T cells perform RNA-seq and gene expression profile analysis. SOURCE: Paulo Rodriguez Moffitt Cancer Center