Pluto Bioinformatics

GSE148662: CD5 levels define functionally heterogeneous populations of nave human CD4+ T cells

Bulk RNA sequencing

Studies from mouse models show that differences in self-reactivity, as read-out by CD5 levels, identifies nave T cell subsets with distinct functional properties during an immune response. Whether CD5 levels can also be used to parse functional biases in naive human CD4+ T cells is incompletely understood. Our study establishes CD5 as a reliable marker of T cell self-reactivity and functional heterogeneity in human CD4+ T cells. SOURCE: Heather Melichar (heather.melichar@umontreal.ca) - Maisonneuve-Rosemont Hospital Research Center