Beta cells are the sole source of insulin in our body, yet we do not understand how they mature into fully functional, glucose-responsive beta cells. We discovered a persistent population of immature beta cells that is marked by the absence of Ucn3 and is functionally immature. We generated transcriptomes of these immature beta cells, along with mature beta cells and the mixed pool of non-beta cells from the same islets. This enables a systematic comparison across thousands of genes between two distinct maturation stages of the beta cell. SOURCE: Mark,O.,Huising (mhuising@ucdavis.edu) - Huising lab University of California, Davis

Pluto Bioinformatics

GSE88778: Virgin Beta Cells Persist throughout Life at a Neogenic Niche within Pancreatic Islets