Pluto Bioinformatics

GSE139325: Targeting CD36-PPAR signaling-mediated metabolic adaptation in intratumoral Tregs primes tumors for PD-1 blockade

Bulk RNA sequencing

Though high frequency of Tregs in tumor obstructs anti-tumor immune responses, systemic depletion of Tregs caused severe autoimmune disease in mice model. Therefore, specifically targeting intratumoral Tregs is direly needed to fight against tumor. Our study provides a novel approach to target intratumoral Tregs to enhance anti-tumor immunotherapy. SOURCE: Ping-Chih Ho (ping-chih.ho@unil.ch) - Immunometabolic regulation University of Lausanne