Pluto Bioinformatics

GSE122088: Loss of the FAT1 tumor suppressor promotes resistance to CDK4/6 inhibitors via the Hippo pathway

Bulk RNA sequencing

Loss of FAT1 promotes resistance to CDK4/6 inhibitors. This study was to compare the differential mRNA expression of FAT1 crispr cells with parental cells, to identify the underlying mechanisms of resistance. SOURCE: Sarat CHANDARLAPATY Memorial Sloan-Kettering Cancer Center