Pluto Bioinformatics

GSE134779: Transcriptomic analysis of Tregs from RelB-dDC mice

Bulk RNA sequencing

We report here the effect of RelB ablation in CD11c+ cells on the Treg compartment accross various organs.This mice have been backcrossed to a Foxp3 reporter mouse line to enable cell sorting of Tregs with a high purity. Interestingly, RelB ablation in DCs leads to a substantial accumulation of Tregs and these Tregs show a 'tissue Treg' signature including high expression levels of KLRG1, I1LRL1 and Gata3 when compared to Tregs of littermate control mice. SOURCE: Caspar Ohnamcht (caspar.ohnmacht@helmholtz-muenchen.de) - Mucosal Immunology Helmholtz Center Munich