Septic shock is the most severe complication of sepsis, associated with high mortality. The patients response to supportive therapy is very heterogeneous and the underlying mechanisms are still elusive. In order to identify which are the actors (genes and pathways) that play a role in establishing the response, we investigate the whole blood transcriptome in septic shock patients with positive and negative responses to early supportive hemodynamic therapy, assessed by changes in SOFA scores within the first 48 hours from ICU admission. We pinpointed genes and pathways that are differently modulated and enriched respectively within 48hrs between responders and non-responders. SOURCE: Matteo Barcella (matteo.barcella@unimi.it) -  Università di Milano

Pluto Bioinformatics

GSE110487: Whole blood transcriptome analysis of Septic shock patients according to early therapy response