Pluto Bioinformatics

GSE110404: BONE MORPHOGENETIC PROTEIN 8B (BMP8B) IN NON-ALCOHOLIC STEATOHEPATITIS (NASH) AND ACUTE HEPATIC DAMAGE

Bulk RNA sequencing

TGF/BMP family member Bone Morphogenetic Protein 8b (Bmp8b) is upregulated in NASH (Western Diet -WD- Model) and acute liver damage (CCl4 model). Absence of Bmp8b reduces liver inflammation and fibrosis in the NASH model (WD). In the acute (3days) CCl4 model, absence of Bmp8b impacts acute inflammatory responses and hepatic stellate cells (HSC) activation. BMP8b is thus a pathophysiologically relevant target to modulate inflammation and fibrosis in liver disease and, in specific, in NASH. SOURCE: Brian,Yee Hong,Lam (yhbl2@cam.ac.uk) - University of Cambridge