The goal of this study was to determine if fibroblasts from different origin (skin, colon, tumors) were keeping their characteristic while extracted and cultured ex vivo for several passages. HUVEC was used as a control, being cells from a different background. Surprisingly, fibroblasts from different origins are losing their independant characteristic to cluster in a similar way after 5-6 passages in culture in vitro, showing an activated status. SOURCE: Rüegg Curzio (curzio.ruegg@unifr.ch) - Pathology Université de Fribourg

Pluto Bioinformatics

GSE67945: Investigation about fibroblasts of different origins in culture