Pluto Bioinformatics

GSE150825: Single-cell sequencing of infiltrating stromal cells in nasopharyngral carcinoma

Bulk RNA sequencing

The tumor microenvironment (TME) of nasopharyngeal carcinoma (NPC) harbors a heterogeneous and dynamic stromal population. A comprehensive understanding of this tumor-specific ecosystem is necessary to enhance the cancer diagnosis, treatment, and prognosis.Therefore, we applied single-cell RNA sequencing to patients with nasopharyngeal carcinoma and nasopharyngeal lymphoid hyperplasia, integrated with additional clonotype identification on T and B cells. Together, these data facilitate the understanding of the stromal landscape and dynamics in NPC patients and provides deeper insights into the development of prognostic biomarkers and therapeutic targets in the TME. SOURCE: Lanqi Gong (lqgong@connect.hku.hk) - The University of Hong Kong