Pluto Bioinformatics

GSE50927: RNAseq on lungs from WT vs claudin 4 KO mice that underwent ventilator-induced lung injury

Bulk RNA sequencing

WT mice and claudin 4 KO mice were exposed to ventilator-induced lung injury (VILI) for 2 hours. We found that in some Cldn4 KO mice, injury was similar to WT, while in others, injury was higher, as assessed by amount of protein leak into broncho-alveolar lavage fluid. We performed RNAseq to find which genes were responsible for higher injury in Cldn4 KO mice. SOURCE: Zea Borok (zborok@usc.edu) - Borok University of Southern California