The farnesoid X receptor (FXR) is a nuclear receptor activated by bile acids that regulates bile acid metabolism, glucose and cholesterol homeostasis. FXR is expressed as four isoforms (1-4), and their relative abundance is tissue specific. Human livers express predominantly FXR isoforms 1 and 2. From mouse studies we know that the FXR agonist obeticholic acid (OCA) regulates expression of many genes in the liver. However,  there is currently no data on the effects of OCA on FXR isoform selective gene regulation.  This is particularly relevant since the relative FXR isoform amounts in the liver are regulated by general bioenergetic cues (Correia JC et al. 2015). In this study we investigate the effect of variations in FXR isoforms 1 or 2 expression on HepG2 cell lines response to treatment with OCA. SOURCE: Jose Miguel Ramos Pittol (Jose.Ramos-Pittol@uibk.ac.at) -  UMC Utrecht

Pluto Bioinformatics

GSE133659: FXR isoform selective effects on hepatoma cell line HepG2