Pluto Bioinformatics

GSE145232: High glucose levels increase influenza-associated damage to the pulmonary epithelial-endothelial barrier

Bulk RNA sequencing

Here, the effects of high glucose levels on influenza severity were investigated using an in vitro model of the pulmonary epithelial-endothelial barrier. We show that compared to low glucose levels, high glucose conditions prior to influenza A virus infection increased virus-induced barrier damage. Increased barrier damage was not associated with increased cell death nor increased virus replication, but rather an increased pro-inflammatory response in endothelial cells and the subsequent damage of the epithelial junctional complex. SOURCE: Kyle,R,Upton (kyle.upton.is@gmail.com) - Upton University of Queensland