Pluto Bioinformatics

GSE129619: Disease modelling of core pre-mRNA splicing factor haploinsufficiency

Bulk RNA sequencing

We generated a human EFTUD2 knockdown cell line using a CRISPR cas9 nickase strategy to investigate the effects of decreased expression of core spliceosome components on cell characteristics and global transcriptome expression/splicing patterns SOURCE: Huw,Batten,Thomas (huw.thomas@manchester.ac.uk) - Michael Smith Building University of Manchester