Pluto Bioinformatics

GSE83394: Chromatin access at specific genome sites distinguishes intestinal crypt populations with stem cell potential

Bulk RNA sequencing

To define differences in chormatin accessibility and histome modifications in intestinal stem and epithelial cells, we performed ATAC-seq and ChIP-seq.; We used RNA-sequencing to profile gene expression changes during intestinal stem cell differentiation into different cell types. We find that gene expression is correlated with the chromatin accessibility and reveals differences between intestinal stem cells types. SOURCE: Ramesh,Arjun,Shivdasani (Ramesh_Shivdasani@dfci.harvard.edu) - Shivdasani Dana Farber Cancer Institute