Pluto Bioinformatics

GSE149565: EDF1 binds collided ribosomes and facilitates recruitment of translational repressors GIGYF2/EIF4E2 and initiates JUN-mediated transcriptional response

Bulk RNA sequencing

RNA-seq analyses of wild-type and DEDF1 cell lines show that the immediate-early JUN-dependent transcriptional response to collisions is dependent on EDF1. SOURCE: Boris Zinshteyn (borisz@jhmi.edu) - Green Johns Hopkins University School of Medicine