Pluto Bioinformatics

GSE119484: Hif-1alpha deletion leads to adverse treatment efficacy in a mouse model of MLL-AF9 driven AML

Bulk RNA sequencing

This report explores the effect of Hif-1alpha deletion, using a conditional mouse model, together with standard chemotherapy regimen to evaluate leukemia stem cell (LSC) targeting in a murine model of MLL-AF9 driven acute myeloid leukemia (AML). This study reveals that Hif-1alpha-deleted leukemias displayed a faster disease progression after chemotherapy. SOURCE: Shamit Soneji BMC