Pluto Bioinformatics

GSE109633: Effects of Hif1a mutation and maternal diabetes on the offspring heart

Bulk RNA sequencing

We analysed the combined effects of exposure to maternal diabetes and disrupted HIF-1 signaling on the transcriptom in cardiac left ventricles of 12 weeks old male mice. This approach provides the information about the long term changes originating in utero due to maternal diabetes and inefficient response to hypoxia which develops as a result of hyperglycemia. The majority of changes were detected in Hif1a insufficient mice exposed to maternal diabetes. SOURCE: Gabriela Pavlínková Institute of Biotechnology, CAS, v.v.i