Pluto Bioinformatics

GSE133660: Gene expression data from IMR90 control, IMR90 shRRM2 and shRRM2/shp16

Bulk RNA sequencing

Transformed and tumorigenic cells require increased deoxyribonucleotide synthesis to fuel the genome replication that sustains their unregulated cell cycle and proliferation. Therefore, it is likely that the cell cycle and nucleotide metabolism are linked. The cell cycle inhibitor p16 is a critical tumor suppressor that is lost as an early event in many human cancers. While loss of p16 is known to play a role in deregulating the cell cycle, whether loss of p16 expression affects nucleotide metabolism is unknown. SOURCE: Raquel Buj (rbujgomez@pennstatehealth.psu.edu) - Aird Penn State College of Medicine