Pluto Bioinformatics

GSE134713: Proteinase-Activated Receptor 4 (PAR4) mediates cell membrane blebbing in a Gaq/11, Gai independent, RhoA and -arrestin-dependent manner.

Bulk RNA sequencing

To gain a comprehensive understanding of *-arrestin mediated signaling downstream of PAR4 and to guide future studies, we undertook RNAseq analysis of PAR4 activated genes in control cells and in cells lacking *-arrestin-1/-2. The results of this analysis revealed PAR4 regulation of genes involved in processes including blood coagulation and circulation, cell-cell adhesion, sensory perception and neuron-neuron synaptic transmission, terms that relates back to known function of PAR4. SOURCE: Jamie,M,Kramer (james.kramer@schulich.uwo.ca) - University of Western Ontario